Journal article
From niche methods to necessary tools: The growing importance of analytical atomic spectrometry in metal imaging in neuroscience
EJ McAllum, DJ Hare
Spectrochimica Acta Part B Atomic Spectroscopy | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2019
Abstract
Visualizing the highly compartmentalized distribution of metals in the brain has grown from a handful of analytical method development laboratories to now being an integral part of contemporary neuroscience and medical research. The burgeoning interest in mapping metals in the brain has been spurred on by an increasing appreciation of the role minor and trace elements play in normal neural function, ageing, neuroinflammation, and as a potential causative factor in a range of neurological disorders. Advances in technology, development of versatile imaging protocols, and an array of data analysis resources have all contributed to the current status of quantitative metal imaging as an invaluabl..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
EJM is a National Health and Medical Research Council-Australian Research Council Dementia Research Development Fellow (GNT1105791). DJH is supported by a National Health and Medical Research Council Career Development Fellowship (Industry) in partnership with Agilent Technologies Australia (GNT1122981). Both authors would like to acknowledge the generosity of the Argyrou family for their support through the Argyrou Family Fellowship, administered by Parkinson's Victoria. The Florey Institute of Neuroscience and Mental Health acknowledge the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.